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BackgroundObservationalstudiessupportanassociationbetweenalowblood25-hydroxyvitaminDlevelandtheriskoftype2diabetes.However,whethervitaminDsupplementationlowerstheriskofdiabetesisunknown.MethodsIntheD2dstudy,adultswhometatleasttwoofthreeglycemiccriteriaforprediabetes(★plasmaglucoselevel,tomgperdeciliter;plasmaglucoselevel2hoursaftera75-goralglucoseload,tomgperdeciliter;andglycatedhemoglobinlevel,5.7to6.4%)andnodiagnosticcriteriafordiabeteswererandomlyassignedtoreceiveIUperdayofvitaminD3orplacebo,regardlessofthebaselineserum25-hydroxyvitaminDlevel.ResultsBymonth24,themeanserum25-hydroxyvitaminDlevelinthevitaminDgroupwas54.3ngpermilliliter,as